Funding outcome

The role of my project is to understand where and when Cajal-Retzius cells (CRs) begin dying off in the developing brains of control and capicua (CIC) knockout mice. To do this a technique known as iDISCO will be used. iDISCO is a method that visualizes whole tissues by making the tissue optically transparent while labelling the cells of interest with fluorescence. Using this technique, it will be possible to see where the CRs are located throughout the brains of the control and CIC knockout mice. Samples will be collected at various developing stages thus creating a map and timeline of CRs in the developing brain. This project thus serves two main purposes: it will strengthen our understanding of CRs and the processes regulating their death, it will also provide insight into the mechanisms of epileptic disorders.