Funding outcome

We have recently identified that children with end-stage liver disease (ESLD) have sarcopenia (reduced muscle mass) which is associated with adverse operative outcomes (e.g. increased infection, delayed growth and gross motor skill development, longer length of stay/rehospitalization). We have shown that sarcopenia lasts up to 8-10 years after transplantation and that reduced muscle strength, and muscle mass directly influence physical performance and participation in daily physical activity in children after transplantation. All of this can severely impact health-related quality of life (HRQOL) of a child living with liver disease. Hence, development of effective rehabilitation strategies for the treatment of childhood sarcopenia is important because the potential for adverse outcomes into adulthood is high. The goal of this project is to develop an effective treatment of sarcopenia in children with ESLD. This study aims to develop a 12-week, home-based, exercise program comprised of progressive resistance training using video-based technology. This is especially important during the COVID-19 pandemic, as virtual technology provides access for Canadians living in remote areas with limited rehabilitation services. We aim to study whether this exercise program results in improvements in muscle mass, strength and overall ability to participate in routine activities resulting in significant improvements in HRQOL.