Agriculture, Life & Environmental Sciences-Agricultural, Food & Nutritional Science
University of Alberta
Summary of research:
Dr. Vine and the MCVD Laboratory are contributing to the link between intestinal lipid absorption, transport and metabolism in relationship to impaired intestinal chylomicron lipoprotein physiology in cardiovascular disease, metabolic syndrome, polycystic ovarian syndrome and diabetes. Emerging evidence suggest the intestine contributes significantly to whole body cholesterol and triglyceride metabolism, yet there remains a lack of knowledge regarding the regulation of intestinal lipid absorption, and transport of dietary lipids to the circulation via chylomicrons in disease states. In particular, we are interested in how chylomicrons and their remnants independently contribute to cholesterol deposition in the arterial wall and subclinical cardiovascular disease risk. Subclinical cardiovascular disease risk associated with impaired chylomicron metabolism in childhood and adolescent obesity, metabolic syndrome, and polycystic ovary syndrome are being investigated and how diet, exercise and pharmacotherapies can modulate this risk in these conditions.