Retinoblastoma, a childhood tumour of the eye, occurs when both copies of the retinoblastoma (RB) gene are mutated in retinal precursor cells. In spite of extensive investigations of the RB gene, no one truly understands how retinal precursor cells become tumorigenic. We are using different approaches spanning the fields of molecular biology, cellular biology and developmental biology, to study the spectrum of changes in retinal cells compared to retinoblastoma tumour cells. We are particularly interested in a family of proteins called lipid binding proteins. These lipid binding proteins bind fatty acids such as omega-3 fatty acids, as well as retinoic acids. Both omega-3 fatty acids and retinoic acid have been associated with inhibition of tumour growth. By investigating which lipid binding proteins are expressed in pediatric cancers such as retinoblastoma, and adult cancers such as breast cancer, we aim to predict how cancer cells will respond to omega-3 fatty acids and retinoic acid.