Dr. Le's research team develops highly sensitive techniques and assays that enable studies of human exposure to environmental toxicants in water and food. The collaborative work on the determination of arsenic species, assays for trace levels of proteins and DNA damage, and new approaches to detection of these targets have enabled novel environmental and health studies. The team's research has resulted in better detection of environmental contaminants and greater understanding of their health effects, providing a scientific basis for environmental and health protection. Their new techniques are also applied to collaborative studies on cancer causation and therapeutic treatment.