The Davidge laboratory studies cardiovascular physiology with a specific interest in the area of women and perinatal health. Studies include understanding mechanisms of aging and estrogen deficiency (i.e. menopause) on vascular function in order to develop novel therapies for improving vascular health in our aging population. We also study the mechanisms for normal cardiovascular adaptations of pregnancy as well as mechanisms for impaired vascular responses in the pregnancy disorder, preeclampsia. Complications in pregnancy can also influence cardiovascular health in the offspring. Numerous epidemiological studies have determined an association between an adverse perinatal environment and the occurrence of cardiovascular diseases later in life. Our laboratory uses animal models to understand the mechanisms for the effects of a hypoxic intrauterine environment on altered cardiovascular function in offspring. We study both cardiac and vascular function of these offspring at various life stages including fetal, neonatal, young and aged adults.