Fats are essential molecules for cells. Cells are built of fats and use them as a metabolic source of energy. Too much fat, however, is toxic. Therefore, cells have devised strategies to prevent toxicity that arises from too much fat; they transport them to other cells that are better equipped to metabolize the extra fat. This is a particularly important process in the brain, as it contains the highest percentage of fat compared to all other organs in the body. In fact, defects in transporting fat between cells is involved following injury in the developing brain and during stroke in adults. This research project will uncover molecular pathways that regulate fat transport in the brain. Specifically, we are interested in how fat accumulation in the brain makes newborns more vulnerable to brain damage following injury and how it is influences women versus men following stroke.