Medicine & Dentistry-Biochemistry
University of Alberta
Summary of research:
Despite significant advances in the past decade, the regulatory networks responsible for the heart development and congenital heart malformations formation remain poorly understood. Understanding cardiac development and physiopathological mechanisms has been become indispensable for development of new and more efficient ways to cure cardiac diseases. Most importantly, congenital heart anomalies represent the most common human birth defect, and are the leading cause of death in the first year of life. Such defects involve structural abnormalities of the heart, primary cardiac muscle disorders, and disturbances of cardiac rhythm. The objective of our work is to understand, at the molecular level, events associated with cardiac development and congenital pathologies. Furthermore, our research focuses on the development of basic and clinical tools for treatment of cardiac diseases. A better understanding of the molecular events associated with cardiomyocytes differentiation will provide invaluable information for future development of cell and drug therapies for treatment of many cardiac diseases. This will have a major impact on the advancement of research and general knowledge.