Osteoporosis is a bone disease characterized by low bone mass and deteriorated bone tissues and architecture, leading to the risk of fracture. My research team is involved in basic and clinical research utilizing ultrasonic and mechanical techniques to study and image bone tissues, detect fractures, monitor bone healing and guide clinical insertion procedures. Ultrasound renders a potential remote sensing method to evaluate bone quality, especially the mechanical properties of bone. Ultrasonic interaction with bone tissues is complicated and the understanding of the underlying mechanisms will ultimately help us derive better mathematical bone models and methodologies to assist in the interpretation of clinical data. Other imaging modalities such as CT, micro-CT and MRI will be used to supplement the studies.