Jeff D Fuller
Medicine & Dentistry-Laboratory Medicine & Pathology
University of Alberta
PhD, FCCM, ABMM
Summary of research:
Human papillomavirus infection is associated with 99.8% of cervical cancer. The treatment of moderate to severe dysplasia is surgical resection; however, 25% of women remain infected with the causative HPV and are at risk of developing cervical cancer. The medical management following surgery focuses on detecting persistent HPV infections that may lead to recurrent disease. Techniques include cytopathology, colposcopy, and HPV testing. However, there is conflicting evidence supporting the effectiveness of these procedures. The oncogenic potential of a type-specific HPV infection is related to viral E6 and E7 proteins. The focus of our research is to characterize a quantifiable association of E6 and E7 mRNA production with persistent HPV infection and recurrent disease following medical intervention. In collaboration with Pathology and Obstetrics services, University of Alberta Hospital, we are longitudinally following patients referred to the Cross Cancer Institute for colposcopic management into our study program. Cervical specimens from our cohort are to be analyzed on a molecular level to determine HPV infectivity in correlation to patient cytopathology and progression or regression over time.