The research focus of the Hammond laboratory is on the pharmacological, functional and molecular characterization of the membrane transport systems responsible for the uptake and release of endogenous purines and anticancer/antiviral purine analogues by mammalian cells. Examples drugs include AraC used in blood cancers, gemcitabine in pancreatic and breast cancers, and 6-mercaptopurine used in both pediatric leukemias and inflammatory bowel diseases (e.g. Crohn's disease). These drugs must enter cells to achieve their therapeutic effects. Therefore changes in the function and number of the transporter protein can impact the dosage required for adequate treatment with minimal side effects. Our studies aid in the understanding of how one can manipulate these transporters to enhance the therapeutic activities of purine based drugs.