Medicine & Dentistry-Laboratory Medicine & Pathology
University of Alberta
Summary of research:
I am a pathologist and researcher at the Department of Laboratory Medicine and Pathology (Royal Alexandra Hospital and University of Alberta). I am interested in cancer of the gynecologic tract, including ovarian cancer and uterine cancer, and cancer from the musculoskeletal system (sarcoma, the second most common group of cancer in children). My goal is to incorporate scientific knowledge about these cancers into the prevention, early detection, diagnosis (classification) and clinical management of these cancers. Below is an example of the type of study I am undertaking to improve diagnosis of uterine cancer. Study on uterine cancer: Endometrial cancer is a cancer that arises from the lining of the uterus. It is the most common type of cancer of a woman's reproductive system and the fourth most common cancer type among women. Not all endometrial cancers are the same and they are separated into different subtypes. Some subtypes of endometrial cancer are more aggressive than others, and they are treated differently based on how aggressive they are known to be. Therefore, it is important to accurately subtype them. However, the way we currently subtype endometrial cancer is inconsistent because of inherent limitation in its methodology. In this study, we will use advanced study methods that incorporate our genetic understanding to subtype endometrial cancers. We plan to develop diagnostic approach and algorithm that will allow more accurate and objective distinction between different subtypes. This can be utilized by all diagnostic laboratories. Ultimately, this study will give the patients and their health care providers more accurate information about the cancer and collectively plan the most appropriate management strategy for it.