The treatment of cervical cancer often involves brachytherapy. Traditionally, brachytherapy was delivered using a low-dose rate regime where low dose rate sources deliver dose continuously for approximately 2 days. However, in recent years different types of deliveries have become common: high dose rate fractionated doses delivered in a few sessions; and pulsed dose rate deliveries where short dose pulses are repeated hourly over approximately 2 days. Radiobiologically, different dose rates result in different tumor and normal tissue responses. Mathematical models are used to try to predict equivalence between different types of deliveries. Our project attempts to use these models to optimize the parameters of these new delivery techniques to maximize tumor control and minimize toxicity, and to perform experiments to better understand/determine the radiobiological response parameters on which the models rely.