Rene L Jacobs


Obesity, a consequence of multifaceted interactions between genetic and environmental factors, is reaching epidemic proportions in Western countries. The increase in adiposity is correlated with the growing numbers of people inflicted with Type 2 Diabetes Mellitus (T2DM). The rate of both atherosclerosis and fatty liver disease is significantly elevated in those with obesity and Type 2 Diabetes. To regulate energy metabolism, tissues/organs must communicate metabolic information to each other. This process consists not only of circulating factors (such as nutrients, hormones, and adipokines), but also neuronal signals from the autonomic nervous system. The long-term goals for my research program are: 1. To understand the tissue-specific role of phospholipid synthesis on the development of obesity; 2. Investigate the importance of dietary choline (and related nutrients) supply in regulating lipid metabolism and immune function during pregnancy and lactation.