R Todd Alexander


The focus of Dr. Alexander's research is primary transport mechanisms by which the renal tubule and intestinal epithelia regulate the body's electrolyte, and acid/base balance. In particular, he seeks to understand the molecular mechanisms responsible for altered tubular divalent cation reabsorption and their effects on calcium homeostasis; in particular how they cause kidney stones in children and osteoporosis. He also seeks to identify the molecules mediating intestinal phosphate absorption with the aim to target them for the treatment of hyperphosphatemia, a condition common in children with kidney disease. Finally Dr. Alexander seeks to identify novel causes of disease affecting blood electrolyte levels.

Stories this researcher is featured in:

May 15, 2023

Diving deep into DNA to help a child with hereditary rickets

Asra Almubarak investigates gene mutations implicated in a case of rickets to pinpoint the cause.

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July 11, 2022

Unlocking the mysteries of biology

A fundamental question about calcium reabsorption in the kidney is finally answered

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March 31, 2022

Funding boost builds capacity for kidney research through expanded education and training

Increasing the number of well-trained researchers will help address rising rates and health-care costs of kidney disease in Canada.

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January 12, 2022

FoMD faculty member renewed as Canada Research Chair

Todd Alexander discusses his vision for the next five years as a renewed CRC.

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September 9, 2020

WCHRI welcomes Todd Alexander as associate director

The Women and Children’s Health Research Institute is pleased to announce the appointment of Todd Alexander as associate director.

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August 29, 2018

New drug could ease the burden of chronic kidney disease for children

Todd Alexander is investigating how a new drug, which inhibits sodium absorption, also helps prevent high blood phosphorus levels.

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