R Todd Alexander
- Faculty: Medicine & Dentistry-Pediatrics
- Position: Professor
- Research Areas: Hypercalciuria, Kidney, Nephrons, Osteoporosis, Sodium, Sodium Chloride, Sodium-Hydrogen Exchanger 3, Water
- Research Theme: Children's Health & Well-being
Summary:The focus of Dr. Alexander's research is primary transport mechanisms by which the renal tubule and intestinal epithelia regulate the body's electrolyte, and acid/base balance. In particular, he seeks to understand the molecular mechanisms responsible for altered tubular divalent cation reabsorption and their effects on calcium homeostasis; in particular how they cause kidney stones in children and osteoporosis. He also seeks to identify the molecules mediating intestinal phosphate absorption with the aim to target them for the treatment of hyperphosphatemia, a condition common in children with kidney disease. Finally Dr. Alexander seeks to identify novel causes of disease affecting blood electrolyte levels.
Stories this researcher is featured in:
Diving deep into DNA to help a child with hereditary rickets
Asra Almubarak investigates gene mutations implicated in a case of rickets to pinpoint the cause.
Unlocking the mysteries of biology
A fundamental question about calcium reabsorption in the kidney is finally answered
Funding boost builds capacity for kidney research through expanded education and training
Increasing the number of well-trained researchers will help address rising rates and health-care costs of kidney disease in Canada.
FoMD faculty member renewed as Canada Research Chair
Todd Alexander discusses his vision for the next five years as a renewed CRC.
WCHRI welcomes Todd Alexander as associate director
The Women and Children’s Health Research Institute is pleased to announce the appointment of Todd Alexander as associate director.
New drug could ease the burden of chronic kidney disease for children
Todd Alexander is investigating how a new drug, which inhibits sodium absorption, also helps prevent high blood phosphorus levels.