Lawrence H Le


Osteoporosis is a bone disease characterized by low bone mass and deteriorated bone tissues and architecture, leading to fracture risk. Osteoporosis is a wide-spread systemic disorder of the skeleton which raises a significant challenge to health care systems worldwide. Osteoporosis affects up to 15.8% of women over the age of 50 years. The rate of bone loss is greater in women than men with women experiencing accelerated bone loss following menopause. The disease however can strike at any age. My research team is involved in basic and clinical research utilizing ultrasonic and mechanical techniques to study and image bone tissues, detect fractures, monitor bone healing and guide clinical insertion procedures. Ultrasound renders a potential remote sensing method to evaluate bone quality, especially the mechanical properties of bone. Ultrasonic interaction with bone tissues is complicated and the understanding of the underlying mechanisms will ultimately help us derive better mathematical bone models and methodologies to assist in the interpretation of clinical data. Other imaging modalities such as CT, micro-CT and MRI will be used to supplement the studies

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