Khaled H. S. Barakat

Summary:

Barakat's lab research stands at the multidisciplinary interface of physics, biology and computer science. His research is focused on understanding the structure-function-relationship of cardiac ion channels in health and disease and on developing and applying state-of-the-art computational drug discovery tools to discover new anticancer, antiviral and immunotherapeutic small molecule drugs. Studies in Barakat's lab include the development of small molecule inhibitors targeting the immune checkpoints receptors, PD-1 and CTLA-4 as well as the phosphatase, SHP-2 towards identifying safe and effective treatments against triple negative breast cancer (TNBC). Further studies in Dr. Barakat's lab is focused on developing inhibitors for the nucleotide excision repair (NER) pathway for the treatment of breast cancer.