Ayman El-Kadi

Summary:

Menopause is the permanent cessation of menstruation and ovarian follicular production of estrogens and progesterone. Numerous observational, retrospective, interventional, and meta-analysis studies showed that ovarian steroids exert protective effects in women and the absence of hormones after menopause makes postmenopausal women more vulnerable to cardiovascular diseases such as heart failure. My goal is to understand the role of cytochrome P450 (CYP) enzymes, the enzyme that form cardioprotective and cardiotoxic metabolites, in the pathogenesis of cardiovascular diseases during menopause. Understanding the pathogenesis of cardiac hypertrophy may provide important clues for the development of rational therapies for the prevention and treatment of heart failure in women and men. The development of these rational therapies will decrease morbidity and mortality and hence diminish health care costs and enhance patient quality of life.